Manufacturing could be considered at the historical level the “Digital Twin” of human skills evolution. It reflects our growth and ability to build tools, goods, to overcome challenges. Nevertheless, it is one that very special area of our societies where human mind turned skills in complex tools. Industrial revolution and its disruptive impact over the ages is peered by other probably less observed major changes in societies. Those ones, like accessibility of education, communication and travel means, accelerate, and deliver inputs for new waves of growth, efficiency, and diversity in manufacturing. All those cycles of complexity growth refined the understanding, preventing, monitoring and reacting to threats related to safety, security and privacy of humans, machines and processes.